Abstract: Epigenetics refers to the study of heritable changes in gene function or chromosome expression that occur without a change in the sequence of the DNA. The abnormal epigenetic expression plays an important role in the tumor development. Uveal melanoma is the most common intraocular malignant tumor in adults. The emerging emphasis on epigenetic mechanisms in the studies of this disease represents a new research direction.  Relevant researches show that the abnormal epigenetic expression of DNA, such as methylation, histone modification, and miRNA misexpression may have some type of correlational relationships with the development of uveal melanoma.  These findings may provide new possibilities for early diagnosis, treatment, and sequela prevention of uveal melanoma. (Int Rev Ophthalmol, 2013, 37: 384-387)